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KMID : 0380620160480040384
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Korean Journal of Food Science and Technology
2016 Volume.48 No. 4 p.384 ~ p.391
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Effects of ethanol extract of Polygonatum sibiricum rhizome on obesity-related genes
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Jeon Woo-Jin
Lee Do-Seop
Shon Suh-Youn
Seo Yun-Ji
Yeon Seung-Woo
Kang Jae-Hoon
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Abstract
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In previous studies, we confirmed that the ethanol extract of Polygonatum sibiricum (ID1216) has anti-obesity effects on high-fat diet-fed mice. To identify the obesity-related genes affected by ID1216, we studied its effects both in vivo and in vitro. In mice, single administration of ID1216 increased the expression of obesity-related genes including sirtuin1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) and peroxisome proliferator-activated receptor α (PPARα) compared to that in mice administered the vehicle; their downstream genes (uncoupling proteins, acyl-CoA oxidase, adipocyte protein 2, and hormone-sensitive lipase) were also increased by ID1216. In fully differentiated 3T3-L1 adipocytes, ID1216 showed the same effects on anti-obesity genes as those in the animal model. Based on these results, we propose that ID1216 has anti-obesity effects by regulating the SIRT1-PGC1α-PPARα pathway and their downstream genes, thereby controlling energy and lipid metabolisms.
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KEYWORD
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Polygonatum sibiricum, obesity, energy metabolism, lipid metabolism
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